Julie BROGGI

julie.broggi@univ-amu.fr

Associate professor, Institute of Radical Chemsitry (ICR) at Aix Marseille University (AMU)

  • RESEARCH INTEREST

My research focus on the synthesis and use of nitrogen-containing heterocycles with σ- and π-donor properties. During my career, I worked on σ-donor N-heterocyclic carbenes (NHC) as ligands for new organometallic complexes and use them in catalysis. Since 2012, I develop my own thematic dealing with aminoethylenes, the dimeric form of carbenes, used as organic π-electron donors (OED). I explore (1) new OED structures and (2) their reactivity as reducers. I was the first to improve their attractiveness by designing stable latent precursors (Angew. Chem. Int. Ed. 2018) and developing unprecedented applications in nucleoside (Tetrahedron 2016) or polymer chemistry (Angew. Chem. Int. Ed. 2016).

  • CURRENT POSITION

Since 2011, Associate professor  (Maître de Conférences), Institute of Radical Chemistry (ICR),

Faculty of Pharmacy – Aix-Marseille University (France)

“Design of polyvalent organic electron donors (OED): Applications in organic and polymer synthesis”

  • Synthesis of new OED for chemoselective single or double-electron transfer reductions
  • Developing air-stable precursors of OED
  • OED-initiated polymerization reactions
  • PREVIOUS POSITIONS

2010    Teaching assistant (ATER – 12 Months) with Prof. P. Vanelle, Institute of Radical Chemistry (ICR) Faculty of Pharmacy – Aix-Marseille University (France)

  • OED-promoted functionalization of nucleoside analogues

2009    Post-doctoral researcher (12 Months) with Prof. S.P. Nolan, EaStCHEM Research school of Chemistry, University of St Andrews (United Kingdom)

  • EuMet European project (FP7/2007-2013-CP-FP-211468): Synthesis and application in metathesis catalysis of NHC-ruthenium complexes
  • Synthesis of imidazolium salts and the corresponding carbenes. Work in glovebox
  • Mechanistic study of Pd-catalyzed transfer-hydrogenation reactions by low-temperature NMR and isotopic labelling
  • Synthesis and X-ray characterization of air- and ambient temperature-sensitive species
  • EDUCATION

2009    PhD in Organic Chemistry, 1st class honours, with Prof. L.A. Agrofoglio, Dr. S. Berteina-Raboin, Institute of Organic and Analytical Chemistry (ICOA) – University of Orléans (France)

“Contribution of N-heterocyclic carbene(NHC)-containing catalysts in the nucleoside chemistry”

  • Developing NHC-CuI catalyzed cycloadditions => Triazolo-carbanucleosides
  • Developing NHC-RuII catalyzed cross-metathesis => Acyclic phosphononucleosides
  • Synthesis of anti-smallpox nucleosides in racemic or enantiopure series

16-Month internship with Prof. S.P. Nolan, Catalan Institute of Chemical Research (ICIQ), Tarragona (Spain)

  • Synthesis and evaluation of NHC-Palladacycles in the Buchwald-Hartwig N– and O-Arylation
  • Synthesis and evaluation of NHC/PR3-Pd0 in transfer-hydrogenation with formic acid as H-donor

2005     Master of Science (MS) – Therapeutic, Environmental and Material Chemistry, Faculty of Science – University of Nice Sophia-Antipolis (France)

6-Month internship with Prof. R. Condom, Dr N. Patino, Nice Institute of Chemistry (ICN)

  • Synthesis of new pronucleotides as AZT prodrug including a labile disulfide bond
  • GRANT SUPPORTS

2021-2025    Collaborative research grant (PRC) from the French National Research Agency ANR 20-CE07-0010-02

2018-2022     Industrial Post-doctoral fellowship from Ivoclar Vivadent (Leading international dental company – Liechtenstein)

2017-2022    Young researcher grant (JCJC) from the French National Research Agency ANR 17-CE07-000101

2017    French Doctoral research fellowship from the French Ministry of Research

2017    Chinese Doctoral research fellowship from the China Scholarship Council

2014-2016 Inter-team Master project grants from the Institute of Radical Chemistry

2012    Quality Research Bonus from Aix-Marseille University for the purchase of a glovebox

  • TEACHING ACTIVITIES

Since 2011,  Lecturer of Aix-Marseille University (France):

  • Pharmacy Dept.: Organic and therapeutic Chemistry courses for bachelor’s and master’s degree.
  • Chemistry Dept.: Therapeutic Chemistry courses for master’s degree.
  • Life sciences Dept.: Organic and analytical Chemistry courses for bachelor’s degree.
  • Health Dept. (University of Nice): Head of an organic chemistry teaching unit for bachelor’s degree.

2010 Aix-Marseille University: Teaching assistant, hydrology and organic chemistry courses

2007 University of Orléans: Teaching assistant, practical organic chemistry classes

  • ORGANISATION OF SCIENTIFIC MEETINGS

2018 Co-President of the 10th Organic Chemistry Meeting of Marseille

2016 Organizing committee of the 9th Organic Chemistry Meeting of Marseille

  • COMMISSIONS OF TRUST

Since 2018 Reviewer for the ACS Petroleum Research Fund (ACS PRF)

Since 2018 Reviewer for the French National Research Agency (ANR)

Since 2017 Selection committee for 2 lecturer positions (Aix-Marseille University, University of Lyon)

Since 2016 External examiner of 2 PhD thesis defence (Aix-Marseille University, University of Lyon)

Since 2012 Reviewer for several scientific journals, editors: Thieme, Beilstein-Institut or TKS Publisher

  • INSTITUTIONAL RESPONSIBILITIES

2018-2022 Elected member of the scientific council – Institute of Radical Chemistry (ICR), Marseille (France)

2018-2022 Elected member of the teaching service commission – Faculty of Pharmacy, Marseille (France)

Since 2006 Member of the French Chemical Society

  • MAJOR ESTABLISHED COLLABORATIONS

2021, Dr David Martin, Univ. Grenoble Alpes – DCM, Grenoble (France)

Aldehydes as metal surrogates for reductions.

2018, Ivoclar Vivadent Leading international dental company, Schaan (Liechtenstein)

New redox initiators for luting materials and dental composites.

2018, Méditerranée Infection Foundation (UHI, Marseille, France)

Antiparasite activity of azolium salts and associated polymers.

2017, Prof Helmut Schlaad, University of Potsdam (Germany)

Organic electron donors-initiated polymerization of carbohydrate derivatives.

2017, Collaborative project between the Alternative Energies and Atomic Energy Commission CEA, the Mediterranean Institute of Biodiversity, Land and Marine Ecology IMBE, the Laboratory of Divided Materials, Interfaces, Reactivity and Electrochemistry MADIREL and the European Center of Research in Medical imaging CERIMED (France). Materials via Thermodynamics of Interaction and Synthesis for lanthanides Separation.

2011, Prof Stanislaw F. Wnuk, Florida International University (USA), and Dr Maurice Médebielle, University of Lyon (France) – OED-Initiated reduction of nucleoside derivatives.

  • PRIZES AND AWARDS

2018 AMU “PEDR”, award for excellence in research and tutoring

2018 Teaching discharge for research leave allocated by Aix-Marseille University

2017 Best oral communication prize, Organic chemistry congress (GECO58 – Dinard, France)

Guy Ourisson – French Chemical Society Prize

2012 Young Research Investigator Award, City of Marseille (France)

  • LANGUAGES

English, Spanish, French.

  • INVITED LECTURES
  1. 9th Pacific Symposium on Radical Chemistry – June 16-21, 2019 – Pacific Grove, CA, USA – “Organic Electron Donors: Recent developments and applications”
  2. ETRADEM Workshop “Electron Transfer, Radical Ions and Radical Chemistry”– Mars 23-24, 2017 – Lyon, France – “New horizons for Organic Electron Donors”
  • INVITED SEMINARS:
  1. Université de Lyon – November 12, 2018 – Lyon, France – “In-situ generation of powerful organic reducers”
  2. Ivoclar Vivadent AG – July 24, 2018 – Schaan, Liechenstein – “Organic Electron Donors as efficient polymerization initiators”
  • RESEARCH COMMUNICATIONS
  1. 17th French-American Chemical Society (FACS XVII) – June 03-07, 2018 – Orléans, France.

“Base-free generation of organic electron donors from air-stable precursors”

  1. 10th Organic Chemistry Meeting of Marseille (RCOM10) – May 24-25, 2018 – Marseille, France.

“Carboxylate adducts and Carbonate salts: air- and moisture-stable precursors of Organic Electron Donors”

  1. 58th Organic Chemistry Study Group (GECO58) – Aug-Sept 27-1, 2017 – Dinard, France.

“Extending the Functionality and Practicality of Organic Electron Donors”

Best communication prize – Guy Ourisson SCF-DCO prize

  1. 4th Organic Chemistry Symposium (SyCOCAL IV) – May 21-24, 2006 – Mézière en Brenne, France.

   “Development and application of the « Click » reaction in nucleoside chemistry”

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