Julie BROGGI

julie.broggi@univ-amu.fr

Associate professor, Institute of Radical Chemsitry (ICR) at Aix Marseille University (AMU)

Communication and social media manager of the ICR

Research thematic:  Design of potent organic reducers – Reductive methodologies – (Photo)redox catalysis – Polymer chemistry – Drug vectorization – Synthesis of unstable compounds

• RESEARCH INTEREST

My research focus on the synthesis and use of nitrogen-containing heterocycles with σ- and π-donor properties. During my career, I worked on σ-donor N-heterocyclic carbenes (NHC) as ligands for new organometallic complexes and use them in catalysis. Since 2012, I develop my own thematic dealing with aminoethylenes, the dimeric form of carbenes, used as organic π-electron donors (OED). I explore (1) new OED structures and (2) their reactivity as reducers. I was the first to improve their attractiveness by designing stable latent precursors and developing unprecedented applications in medicinal or polymer chemistry.

• CURRENT POSITION

Since 2011, Associate professor  (Maître de Conférences), Institute of Radical Chemistry (ICR)

Habilitation to conduct researches (HDR) obtained on the 11^th of October 2023

Faculty of Pharmacy – Aix-Marseille University (France)

“Design of polyvalent organic electron donors (OED): Applications in organic and polymer synthesis”

• Synthesis of new OED for chemoselective single or double-electron transfer reductions
• Developing air-stable precursors of OED
• OED-initiated polymerization reactions

• PREVIOUS POSITIONS

2010    Teaching assistant (ATER – 12 Months) with Prof. P. Vanelle, Institute of Radical Chemistry (ICR) Faculty of Pharmacy – Aix-Marseille University (France)

• OED-promoted functionalization of nucleoside analogues

2009    Post-doctoral researcher (12 Months) with Prof. S.P. Nolan, EaStCHEM Research school of Chemistry, University of St Andrews (United Kingdom)

• EuMet European project (FP7/2007-2013-CP-FP-211468): Synthesis and application in metathesis catalysis of NHC-ruthenium complexes
• Synthesis of imidazolium salts and the corresponding carbenes. Work in glovebox
• Mechanistic study of Pd-catalyzed transfer-hydrogenation reactions by low-temperature NMR and isotopic labelling
• Synthesis and X-ray characterization of air- and ambient temperature-sensitive species

• EDUCATION

2009    PhD in Organic Chemistry, 1^st class honours, with Prof. L.A. Agrofoglio, Dr. S. Berteina-Raboin, Institute of Organic and Analytical Chemistry (ICOA) – University of Orléans (France)

“Contribution of N-heterocyclic carbene(NHC)-containing catalysts in the nucleoside chemistry”

• Developing NHC-Cu^I catalyzed cycloadditions => Triazolo-carbanucleosides
• Developing NHC-Ru^II catalyzed cross-metathesis => Acyclic phosphononucleosides
• Synthesis of anti-smallpox nucleosides in racemic or enantiopure series

16-Month internship with Prof. S.P. Nolan, Catalan Institute of Chemical Research (ICIQ), Tarragona (Spain)

• Synthesis and evaluation of NHC-Palladacycles in the Buchwald-Hartwig N– and O-Arylation
• Synthesis and evaluation of NHC/PR₃-Pd⁰ in transfer-hydrogenation with formic acid as H-donor

2005     Master of Science (MS) – Therapeutic, Environmental and Material Chemistry, Faculty of Science – University of Nice Sophia-Antipolis (France)

6-Month internship with Prof. R. Condom, Dr N. Patino, Nice Institute of Chemistry (ICN)

• Synthesis of new pronucleotides as AZT prodrug including a labile disulfide bond

• GRANT SUPPORTS

2024    China Scholarship Council grant – Doctoral study grant Nanoconfinement of super-reductive catalysts in supramolecular objects

2024    China Scholarship Council grant – Doctoral study grant Synthesis and late-stage transformation of drugs mediated by organic reducers

2021-2025    Collaborative research grant (PRC) from the French National Research Agency ANR 20-CE07-0010-02

2018-2022     Industrial Post-doctoral fellowship from Ivoclar Vivadent (Leading international dental company – Liechtenstein)

2017-2022    Young researcher grant (JCJC) from the French National Research Agency ANR 17-CE07-000101

2017    French Doctoral research fellowship from the French Ministry of Research

2017    Chinese Doctoral research fellowship from the China Scholarship Council

2014-2016 Inter-team Master project grants from the Institute of Radical Chemistry

2012    Quality Research Bonus from Aix-Marseille University for the purchase of a glovebox

• TEACHING ACTIVITIES

Since 2011,  Lecturer of Aix-Marseille University (France):

• Pharmacy Dept.: Organic and therapeutic Chemistry courses for bachelor’s and master’s degree.
• Chemistry Dept.: Therapeutic Chemistry courses for master’s degree.
• Life sciences Dept.: Organic and analytical Chemistry courses for bachelor’s degree.
• Health Dept. (University of Nice): Head of an organic chemistry teaching unit for bachelor’s degree.

2010 Aix-Marseille University: Teaching assistant, hydrology and organic chemistry courses

2007 University of Orléans: Teaching assistant, practical organic chemistry classes

• ORGANISATION OF SCIENTIFIC MEETINGS

2026 President of the 33^rd Young Research Fellows Meeting of the Society of Therapeutic Chemistry

2025 Member of the organizing committee of the 32^nd Young Research Fellows Meeting of the Society of Therapeutic Chemistry

2018 Co-President of the 10^th Organic Chemistry Meeting of Marseille

2016 Member of the organizing committee of the 9^th Organic Chemistry Meeting of Marseille

• COMMISSIONS OF TRUST

Since 2018 Reviewer for the ACS Petroleum Research Fund (ACS PRF)

Since 2018 Reviewer for the French National Research Agency (ANR)

Since 2017 Selection committee for 6 lecturer positions (Aix-Marseille University, University of Lyon)

Since 2016 External examiner of 11 PhD thesis defence (Aix-Marseille University, University of Lyon)

Since 2012 Reviewer for several scientific journals, editors: Thieme, Beilstein-Institut or TKS Publisher

• INSTITUTIONAL RESPONSIBILITIES

– 2022-2026 Elected member of the Scientific Council of the Faculty of Pharmacy, AMU

– 2018-2029 Elected member of the Laboratory Council of the Institute of Radical Chemistry

– Since 2018 Communication Manager of the Institute of Radical Chemistry

– Since 2018 Site webmaster and social media manager of the ICR social networks

– 2023-2027 Member of the Biatss (non-teaching staff) commission – Faculty of Pharmacy, AMU

– 2018-2022 Member of the Teaching Staff Committee – Faculty of Pharmacy, AMU

– Since 2022 Member of the ICR gender equality working group

– Since 2006 Member of the French Chemical Society and the Society of Therapeutic Chemistry

• MAJOR ESTABLISHED COLLABORATIONS

2021, Dr David Martin, Univ. Grenoble Alpes – DCM, Grenoble (France)

Aldehydes as metal surrogates for reductions.

2018, Ivoclar Vivadent Leading international dental company, Schaan (Liechtenstein)

New redox initiators for luting materials and dental composites.

2018, Méditerranée Infection Foundation (UHI, Marseille, France)

Antiparasite activity of azolium salts and associated polymers.

2017, Prof Helmut Schlaad, University of Potsdam (Germany)

Organic electron donors-initiated polymerization of carbohydrate derivatives.

2017, Collaborative project between the Alternative Energies and Atomic Energy Commission CEA, the Mediterranean Institute of Biodiversity, Land and Marine Ecology IMBE, the Laboratory of Divided Materials, Interfaces, Reactivity and Electrochemistry MADIREL and the European Center of Research in Medical imaging CERIMED (France). Materials via Thermodynamics of Interaction and Synthesis for lanthanides Separation.

2011, Prof Stanislaw F. Wnuk, Florida International University (USA), and Dr Maurice Médebielle, University of Lyon (France) – OED-Initiated reduction of nucleoside derivatives.

• PRIZES AND AWARDS

2023-2026 Compensation system for research and teaching staff – Individual bonus (RIPEC)

2019-2022 Doctoral and research supervision bonus (PEDR)

2018 Leave for research or thematic conversion (CRCT)

2017    Guy Ourisson price SCF-DCO-GECO58, Prize for best oral communication

2012 Young Research Investigator Award, City of Marseille (France)

• LANGUAGES

English, Spanish, French.

• INVITED LECTURES

1. 11^th Franco-Italian Chemistry Days (GIFC) – Torino, Italy – 4-5 April 2024
2. “Reductive reactions catalyzed by super electron donors”
   2. ICR Scientific days – Marseille, France – 9 July 2024

   “α-Trihalomethylated quinolines as safe and storable PET-donor for radical polymerizations”

   3. Molecular Chemistry Dept., Université Grenoble-Alpes – Grenoble, France –22 February 2024

   “Enamine-based organic reducers – from the tool to the applications”

   4. Chemistry Departement, Université de Montpellier – Montpellier, France – 7 December 2023

          “Enamine-based organic reducers, from the tool to the applications”

   5. 13^th Young Investigator Workshop (YIW) – Lisboa, Portugal – 2-4 September 2022

          Invited as the French representative of the Société Chimique de France (SCF)

          “Organic enamine reducers, from the tool to the applications”

   6. 28^th Young Research Fellows Meeting – SCT – Paris, France – 11-12 February 2021

          “The Application Fields of Enamine-based Organic Electron Donors”

   7. 9^th Pacific Symposium on Radical Chemistry (9PSRC) – Pacific Grove, USA – 16-21 June 2019

   Invited as Europe Young Investigators by the organizer Dr Corey Stephenson.

          “Organic Electron Donors: Switching from Radical to Anionic Polymerizations”

   8. Chemistry Departement, Université de Lyon – Lyon, France – 12 November 2018

          “In-situ generation of powerful organic reducers”

   9. Ivoclar AG – Schaan, Liechenstein – 24 July 2018

          “Organic Electron Donors as efficient polymerization initiators”

   10. Electron Transfer, Radical Ions and Radical Chemistry Workshop – Lyon, France – 23-24 March 2017 “New horizons for Organic Electron Donors”
   11. ICR Scientific days – Marseille, France – 10 July 2015

          “Organic Electron Donors: Recent developments and applications

• RESEARCH COMMUNICATIONS

1. 11^th Marseille Organic Chemistry Meetings (RCOM11) – Marseille, France – 10-11 October 2024

“Reductive reactions catalyzed by super electron donors”  

2. Groupe d’Etudes en Chimie Organique (GECO63) – Kerjouanno, France – 27 August – 1 Sept. 2023

“Concomitant Oxidative and Reductive Transformations with Breslow catalysts” 

3. Journées de Chimie Organique (JCO2022) – Palaiseau, France – 2-4 November 2022

“Photocatalysis with super organic electron donors”

4. 8^th EuChemS Chemistry Congress (ECC8) – Lisboa, Portugal – 28 August – 1 Sept. 2022

“Reductive reactions photocatalyzed by super organic electron donors”

5. 3^rd International Conference on Materials Science & Engineering – Boston, USA – 18-22 April 2022

“Switching from Single to Simultaneous Free-Radical and Anionic Polymerization with Enamine-Based Organic Electron Donors”

6. 17^thFrench American Chemical Society (FACS XVII) – Orléans, France – 3-7 June 2018

“Base-free generation of organic electron donors from air-stable precursors”

7. Groupe d’Etudes en Chimie Organique (GECO58) – Dinard, France – 27 August – 1 Sept. 2017

“Extending the Functionality and Practicality of Organic Electron Donors”

8. SyCOCAL IV – Mézière en Brenne, France – 21-24 May 2006

“Development and Applications of the Click Chemistry ”.