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Brevet-2010-2015.

2015


  • Mabrouk, K.; Luis, J.; De, P.; Bertin, D.; Gigmes, D.; Verdoni, M.; Bengeloune, A. H.; Roudaut, H. Use of Spider Venoms for Skin Whitening/Depigmenting and Composition Comprising Spider Venoms Molecules or Synthetic Analogs. EP2892500 (A2) Abstract of corresponding document: EP2705830 (A1), 15 juillet 2015.
    Résumé : The present invention relates to the use of spider venom, fractions or derivatives thereof for skin whitening. The invention also relates to compositions comprising spider venom, fractions or derivatives thereof for skin whitening/depigmenting. The invention finally relates to a non-therapeutic method for whitening human skin comprising topically applying an effective amount on said human skin of the composition of the invention.

  • Mellet, P.; Marque, S.; Franconi, J. - M.; Voisin, P.; Moncelet, D.; Bremond, P.; Audran, G. Alkoxyamines for the Treatment of Cancers. WO2015001436 (A1), 08 janvier 2015.
    Résumé : The present invention relates to alkoxyamines of general formula (I), and to compounds of general formula (lla), (lIb), (lIc), (IId), IIe), (Ilf) or (Ilg), as such and for the treatment of cancers.

2014


  • Berenguer-Daize, C.; Martin, P. - M.; Mabrouk, K.; Bertin, D.; Ouafik, L. 'houcine. Diagnostic and Treatment of an Androgen-Independent Prostate Cancer. US2014308298 (A1), 16 octobre 2014.
    Résumé : The present invention relates to a method for monitoring the tumor growth of an androgen-independent prostate cancer in a subject, by determining the amount of at least one adrenomedullin receptor and optionally adrenomedullin in a prostate cancer cell obtained from said subject. The present invention also relates to a pharmaceutical composition comprising an anti-adrenomedullin antagonist antibody and/or at least one anti-adrenomedullin receptor antagonist antibody for treating an androgen-independent prostate cancer.

  • Bertin, D.; Tran, Q. N.; Phan, T.; Gigmes, D.; Vockenroth, I.; Luneau, B. Use of polymers obtained by copolymerization of styrene sulfonic acid and/or its ammonium or alkali metal with monomer, for enhancing the primary washing power of detergents or cleaning of textiles during washing of its hard surfaces. FR2998304 (A1), 23 mai 2014.
    Résumé : Use of polymers obtained by copolymerization of styrene sulfonic acid and/or its ammonium or alkali metal with monomer (I), for enhancing the primary washing power of detergents or cleaning of textiles during washing or cleaning of textile hard surfaces, as compared to deposits of dirt, is claimed. Use of polymers obtained by copolymerization of styrene sulfonic acid and/or its ammonium or alkali metal with monomer of formula (H 2C=C(R)-C(O)-OX) (I), for enhancing the primary washing power of detergents or cleaning of textiles during washing or cleaning of textile hard surfaces, as compared to deposits of dirt, is claimed. R : H or methyl; and X : linear or branched 1-18C-alkyl. Independent claims are included for: (1) removing deposits of dirt, sensitive to bleaching or enzymes, from hard surfaces of textiles, comprising introducing an agent of washing or cleaning and the polymers; and (2) an agent for washing or cleaning containing the polymers.

  • Bouchet, R.; Aboulaich, A.; Maria, S.; Phan, T.; Gigmes, D.; Bertin, D.; Meziane, R.; Bonnet, J. - P.; Armand, M. Block Copolymer Including a Polyanion Based on a Tfsili Anion Monomer as a Battery Electrolyte. US2014272600 (A1), 18 septembre 2014.
    Résumé : The invention relates to a BA diblock or BAB triblock copolymer, in which the A block is a non-substituted poly-oxyethylene chain having a mean molecular weight that is higher than 100 kDa and the B block is an anionic polymer which can be prepared using one or more monomers selected from among the vinyl monomers and derivatives thereof, said monomers being substituted with a (trifluoromethylsulfonyl)imide (TFSI) anion. The invention also relates to the uses of such a copolymer, in particular for preparing an electrolyte composition for lithium metal polymer (LMP) batteries.

  • Luneau, B.; Kropf, C.; Job, M.; Mussmann, N.; Eiting, T.; Benda, K.; Bastigkeit, T.; Tran, Q. N.; Phan, T.; Gigmes, D.; Bertin, D. Amphiphilic Block Copolymers and Machine Dishwashing Detergents Containing These. WO2014079598 (A1), 30 mai 2014.
    Résumé : It is possible to prevent or at least mitigate discolouration of plastics tableware during machine dishwashing by using amphiphilic block copolymers of -An-Bm- type, where A represents the hydrophilic monomer unit of the hydrophilic block An and B represents the hydrophobic monomer unit of the hydrophobic block Bm and a diene serves as monomer for the hydrophobic monomer unit B.

  • Luneau, B.; Vockenroth, I. K.; Plath, N.; Tran, Q. N.; Phan, T.; Gigmes, D.; Bertin, D. Sulfonate Group-Containing Polymer Active Ingredients Which Improve Primary Detergent Power. WO2014195156 (A1), 11 décembre 2014.
    Résumé : The aim of the invention is to improve the primary detergent power of detergents and cleaning agents, in particular with respect to bleachable and/or enzyme-sensitive soiling. This is substantially achieved by the incorporation of polyesters or polyamides of 5-sulfoisopthalaic acid and a diol and/or a diamine.

  • Luneau, B.; Vockenroth, I. K.; Tran, Q. N.; Phan, T.; Gigmes, D.; Bertin, D. Polymeric Active Ingredients Which Contain Sulfonate Groups and Improve Primary Washing Power. WO2014079786 (A1), 30 mai 2014.
    Résumé : The primary washing power of washing and cleaning compositions was to be improved, especially toward oily and/or greasy stains. This was achieved essentially through the incorporation of polymers containing styrenesulfonic acid.

  • Mabrouk, K.; Luis, J.; De, P. H.; Bertin, D. Use of spider venoms for skin whitening/depigmentating and composition comprising spider venoms derivatives. FR2994847 (A1) Abstract of corresponding document: EP2705830 (A1), 07 mars 2014.
    Résumé : The present invention relates to the use of spider venom, fractions or derivatives thereof for skin whitening. The invention also relates to compositions comprising spider venom, fractions or derivatives thereof for skin whitening/depigmenting. The invention finally relates to a non-therapeutic method for whitening human skin comprising topically applying an effective amount on said human skin of the composition of the invention.

  • Ouari, O.; Tordo, P.; Casano, G.; Rosay, M.; Aussenac, F.; Coperet, C.; Lesage, A.; Rossini, A.; Emsley, L.; Zagdoun, A. Rigid Dinitroxide Biradical Compounds Used as Improved Polarising Agents for Dynamic Nuclear Polarisation Techniques. WO2014170601 (A1), 23 octobre 2014.
    Résumé : The invention concerns a dinitroxide biradical compound, in which the two nitroxide units are held by a rigid linkage, of general formula (I) in which - A is a carbon, an ammonium or a phosphonium, - each of A1 to A6 is selected separately from the group comprising a single bond, O, N, N(O), S, S(O), SO2, C(O), a (C1-C4) alkyl chain, - Z1 and Z2 are chosen from RI and R2 in combination, such that there is always, in the combination, at least one R2 group that needs to be substituted by an R3 group, RI is an H, a (C6-C18) aryl or a (C3-C18) heteroaryl, R2 a (C1-C17) alkyl chain, a (C1-C17) alkenyl chain, a (C1-C17) alkynyl chain, a (C4-C17) cycloalkyl, a (C4-C17) heterocycloalkyl, a (C6-C18) aryl, a (C3-C18) heteroaryl, R3 is a (C1-C17) alkyl chain, a (C1-C17) alkenyl chain, a (C1-C17) alkynyl chain, a (C4-C17) cycloalkyl, a (C4-C17) heterocycloalkyl, a (C6-C18) aryl, a (C3-C18); heteroaryl, an ether -OR, an ester -C(O)O-R (in which R is any hydrocarbon radical), an azide, and in which, when Z1 and Z2 are combined together with the same carbon atom of the nitroxide ring to which they are bonded, they form a spirocycloalkyl or a spiroheterocycloalkyl substituted by R3.

  • Pfeil, A.; Brinkhorst, J.; Gigmes, D.; Valgimigli, L.; Pratt, D.; Bertin, D. Inhibitor Combination, Resin Mixture Containing Same and Use of Same. US2014224424 (A1), 14 août 2014.
    Résumé : The use of a mixture of 5-pyrimidinol derivatives with sterically hindered phenol derivatives for adjusting the reactivity and the gel time of resin mixtures and reactive resin mortars based on radically polymerizable compounds is described. Furthermore, a resin mixture containing the inhibitor combination, a reactive resin mortar containing this resin mixture and two-component mortar systems with the reactive resin mortar according to the invention and a hardener with improved stability in storage and good low-temperature hardening properties are also described. The resin mixture according to the invention is suitable in particular for chemical fastening of construction elements in boreholes in various substrates.

  • Sauvee, C.; Casano, G.; Ouari, O.; Tordo, P.; Aussenac, F.; Rosay, M. Highly Efficient Polarizing Agents for Dynamic Nuclear Polarization. WO2014167121 (A1), 16 octobre 2014.
    Résumé : The invention relates to compounds of general formula (I) wherein X is C=O or SO2, M is NR2 or O, and Q1 and Q2 are nitroxide-containing radicals, and their use as a Dynamic Nuclear Polarization (DNP) agent for polarizing an NMR-active spin of a nucleus of an analyte in Nuclear Magnetic Resonance (NMR) spectroscopy.

2013


  • Duc, M.; Vuillemin, B.; Bertin, D.; Marque, S.; Galindo, C. Process for Preparing High Impact Monovinylaromatic Polymers in the Presence of a Borane Complex. US2013144013 (A1), 06 juin 2013.
    Résumé : The present invention relates to a process for preparing a high impact monovinylaromatic polymer comprising admixing a rubber, at least one monovinylaromatic monomer and optionally one or more comonomer in the presence of at least a borane complex of the L-BH3 type wherein L is a Lewis base and polymerizing the monovinylaromatic monomer. The borane complex initiator, L may be an ether (e.g THF, tetrahydrofurane), a thioether (e.g dimethylthioether) or an amine. A preferred complex is an amine borane such as by way of example triethylamine borane. The present invention also relates to a high impact monovinylaromatic polymer having a weight ratio of grafted monovinylaromatic monomer and optional comonomer to the initial monovinylaromatic monomer and optional comonomer above 0.1%, advantageously above 2% and preferably in the range 2 to 4%. The invention is of particular interest to make high impact polystyrene.

  • Higgins, J.; Cuny, G. D.; Glicksman, M.; Patnaik, D.; Robin, M.; Stein, R. L.; Xian, J. Acridines As Inhibitors Of Haspin And DYRK Kinases. US2013102627 (A1), 25 avril 2013.
    Résumé : The present disclosure is directed to compounds of Formula I: which are inhibitors of Haspin kinase and DYRK kinases. The compounds of the present disclosure, and compositions thereof, are useful in the treatment of disease related to Haspin kinase and DYRK kinase expression and/or activity.

  • Kalyanaraman, B.; Joseph, J.; Schmainda, K. M.; Prah, D. E.; Lopez, M.; Hardy, M. J. In Vivo Mitochondrial Labeling Using Positively-CHarged Nitroxide Enhanced and Gadolinum Chelate Enhanced Magnetic Resonance Imaging. US2013142735 (A1), 06 juin 2013.
    Résumé : A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging data from the subject, and reconstructing an image of the subject having enhanced contrast in areas including metabolic and/or mitotic activity.

  • Lopez, M.; Hardy, M. J.; Kalyanaraman, B.; Zhao, M. 99mTc-LABELED TRIPHENYLPHOSPHONIUM DERIVATIVE CONTRASTING AGENTS AND MOLECULAR PROBES FOR EARLY DETECTION AND IMAGING OF BREAST TUMORS. US2013149240 (A1), 13 juin 2013.
    Résumé : 99mTc-labeled triphenylphosphonium contrasting agents that target the mitochondria and are useful for early detection of breast tumors using scintimammographic imaging. 99mTc-Mito10-MAG3 possesses advantageous radiopharmaceutical properties. The uptake in the myocardium is reduced by one to two orders of magnitude compared to 99mTc-MIBI. 99mTc-Mito10-MAG3 exhibits fast blood clearance, with a blood half-life of less than 2 minutes in rats. A diminished myocardial uptake combined with a prompt reduction of cardiovascular blood pool signal to facilitate improved signal-to-background ratios.

  • Mabrouk, K.; Ouafik, L. 'houcine; Tesic, C.; Bertin, D.; Berenguer-Daize, C.; Martin, P. - M. Antibodies that Bind to Adrenomedullin and to Adrenomedullin Receptors and the Uses Thereof as Drugs. US2013315912 (A1), 28 novembre 2013.
    Résumé : The invention relates to antibodies that bind to adrenomedullin and to proteins forming adrenomedullin receptors and to the uses thereof as drugs.

2012


  • Maas, W.; Rosay, M.; Coperet, C.; Gajan, D.; Emsley, L.; Lelli, M.; Lesage, A.; Rossini, A.; Zagdoun, A.; Tordo, P.; Ouari, O. DNP NMR spectroscopy with non-aqueous solvents. EP2533034 (A1), 12 décembre 2012.
    Résumé : The present invention concerns a method to determine the efficiency of a solvent to impregnate a sample material for use in a dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) experiments, characterized in that the method comprising: - selecting a non-aqueous solvent, - providing a polarizing agent that is soluble in the non-aqueous solvent, - dissolving the polarizing agent in the non-aqueous solvent, - impregnating or dissolving the sample material with the non-aqueous solvent containing the polarizing agent, - performing a solid state DNP NMR experiment on the impregnated sample material, - determining a DNP enhancement factor of the DNP NMR experiment.

2010


  • Ouari, O.; Karoui, H.; Le, M. F.; Tordo, P.; Griffin, R. G.; Matsuki, Y.; Maly, T. Dinitroxide-Type Biradical Compounds Optimized for Dynamic Nuclear Polarization (dnp). US2010249386 (A1), 30 septembre 2010.
    Résumé : The present invention relates to the field of organic chemistry and in particular to organic free radicals used as polarizing agents in the technique of Dynamic Nuclear Polarization (DNP), which involves transferring the polarization of electron spins to the nuclei of a compound whose Nuclear Magnetic Resonance (NMR) is being observed. It concerns dinitroxide-type biradical polarizing agents characterized by a rigid linkage between the nitroxide units that enables optimal orientation and distance to be maintained between the aminoxyl groups of said nitroxide units. This particular structure enables, at low temperatures and high fields, optimal transfer of polarization and optimal enhancement of NMR/MAS signals of the polarized nuclei of the compound studied.
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